2023年獲得圖書館OA補助文章之介紹 (服務辦法)
  • 1. Investigation of High-Sensitivity NO2 Gas Sensors with Ga2O3 Nanorod Sensing Membrane Grown by Hydrothermal Synthesis Method.

    Chu, S.-Y., Wu, M.-J., Yeh, T.-H., Lee, C.-T., & Lee, H.-Y. (2023). Nanomaterials, 13(6), 1064. Read this article

    This study utilized a low-cost hydrothermal method to synthesize gallium oxide hydroxide (GaOOH) nanorods and adopted a high-temperature annealing processes to develop nitrogen dioxide (NO2) gas sensors based on gallium oxide (Ga2O3) nanorods. To achieve a high surface-to-volume ratio of GaOOH nanorods, optimization methods were proposed in this study, including optimizing the thickness of the tin oxide (SnO2) seed layer and the precursor concentrations in the hydrothermal synthesis. In addition, GaOOH nanorods could cause dehydrogenation through annealing process to transform into Ga2O3 nanorods and increased the amount of oxygen vacancy. The optimal surface-to-volume ratio of GaOOH nanorods was obtained by using a 50 nm seed layer and a precursor concentration ratio of Ga(NO3)3·9H2O/HMT of 12 mM/10 mM in the hydrothermal synthesis. Furthermore, the NO2 gas sensors with 400 °C-annealed Ga2O3 nanorod sensing membranes exhibited excellent gas sensing performance. The responsivity was 1184.6% and response and recovery times were 63.6 s and 135.7 s, respectively, under a NO2 concentration of 10 ppm. The sensor was capable of detecting NO2 concentration as low as 100 ppb, with a responsivity of 34.2%. Due to its low-cost production and excellent sensing performance, Ga2O3 nanorods hold great potential for applications in NO2 gas sensors.

    本研究利用低成本水熱法合成氫氧氧鎵(GaOOH)奈米柱並進行熱退火處理以開發氧化鎵(Ga2O3)奈米柱之二氧化氮(NO2)氣體感測器。為了實現高比表面積的氫氧氧鎵奈米柱,本研究提出之優化方式包括氧化錫(SnO2)晶種層的厚度調整以及水熱合成法之前驅物濃度最佳化。此外,研究證實GaOOH奈米柱可以通過熱退火製程使其進行脫氫反應以轉化為氧化鎵奈米柱,並增加其氧空缺含量。研究結果顯示,使用50 nm之晶種層與Ga(NO3)3·9H2O/HMT濃度為12 mM/10 mM之水熱合成法前驅物濃度比,可獲得最佳比表面積氫氧氧鎵奈米柱。此外,氧化鎵奈米柱經400 ℃熱退火處理後所製備而成之二氧化氮氣體感測器具有最佳的特性,在10 ppm的二氧化氮濃度下,其響應度為1184.6%,響應時間為63.6秒,恢復時間為135.7秒,並且可以檢測最低為100 ppb的二氧化氮濃度,其響應度為34.2%,表現出優秀的氣體感測性能。因此,由於其低成本生產和優異的感測性能,氧化鎵奈米柱在二氧化氮氣體感測器中具有極高的應用前景。

  • 2. WiFi-Based Detection of Human Subtle Motion for Health Applications.

    Chen, H.-H., Lin, C.-L., & Chang, C.-H. (2023). Bioengineering, 10(2), 228. Read this article

    Neurodegenerative diseases like Parkinson's affect motor functions, resulting in abnormal movements. These symptoms, including tremors and hand movement disorders, can be subtle and vary daily, making evaluating the disease during a short clinical session challenging. To address the issue, this study presents an approach for detecting human micromotion using Wi-Fi channel state information, enabling home health monitoring and examination in regular-sized rooms. The proposed method was tested on three types of motion, and the results demonstrated that micromotion could be accurately captured at multiple locations within the experimental environment. The computer algorithm achieved an average accuracy of 90.9% (single Wi-Fi link) to 95.7% (multiple Wi-Fi links) in computing the frequency and duration of simulated hand tremors.


  • 3. Thinking more wisely: using the Socratic method to develop critical thinking skills amongst healthcare students.

    Ho, Y.-R., Chen, B.-Y., & Li, C.-M. (2023). BMC Medical Education, 23(1), 173. Read this article

    In medicine, critical thinking is required for managing and tolerating medical uncertainty, as well as solving professional problems and treating diseases. However, the core of Confucianism, teacher-centered and exam-oriented settings in middle and high school education may pose challenges to developing critical thinking in Han Chinese or Taiwanese students. Thus, how to guide students with less stable foundations of critical thinking might require more approach. Almost all healthcare students must complete a biochemistry laboratory course as part of their basic science training. Thus, we aimed to train students to develop critical thinking in the biochemistry laboratory course by using learning sheets and teacher guidance based on the Socratic method and questioning. We recruited second-year students from a medical college, of whom 32 had medical science and biotechnology majors (MSB), 27 had pharmaceutical science majors (PS), and 85 were medical undergraduate (MU) students. Clarity and logic dimensions were identified as the key elements to facilitate the development of critical thinking skills through learning sheets and teacher guidance in students across all three different healthcare majors. The results showed that metacognitive monitoring via Socratic questioning learning sheets have demonstrated potential encourage students to develop critical thinking skills in all dimensions. Another unique contribution of current study was present the heterogeneous learning patterns and progress trajectories of clarity and logic dimensions within classes.


  • 4. Funneling of Oblique Incident Light through Subwavelength Metallic Slits.

    Chen, A. E., Xia, X.-Q., Hong, J.-S., & Chen, K.-R. (2023). Nanomaterials, 13(1), 61. Read this article

    Light funneling determines how enhanced energy flows into subwavelength slits. In contrast to the previous research on oblique incident light, this study reveals that light funneling in the slits can be highly asymmetric, even at small angles. This mechanism is explained by polarized fields and charges, which are induced using Poynting vectors. It is shown that when light is obliquely incident to the slits perforated in a perfect electric conductor, asymmetrical fields and charges accumulate at the upper apex corners of the left (right) sides. When light is incident from the left (right) side, more (less) induced fields and charges accumulate in the left (right) slit corner so that the funneling width, area, and energy flow at the left (right) side increases (decreases).

    光漏斗效應決定了增強能量如何流入次波長狹縫。這項研究揭示了狹縫中的光漏斗在小角度入射下可能是高度不對稱的。這種機制可以通過極化場和電荷以及波印廷向量來解釋。結果顯示,當光線斜向入射完美導體中的狹縫時,不對稱的極化電荷分別累積在左(右)邊的轉角上。當光從左側入射時,會有較多(較少)的電荷累積在左(右)邊 狹縫的轉角,因此左(右)邊的漏斗寬度、面積和能量流增加(減少)。

  • 5. Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents.

    Cheng, P.-N., Sun, H.-Y., Feng, I. C., Wang, S.-T., Chiu, Y.-C., Chiu, H.-C., Chien, S.-C., & Young, K.-C. (2023). Journal of Virus Eradication, 9(1), 100318. Read this article

    Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2’-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p =0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p < 0.0001) and 8-OHdG (p = 0.0255) levels, approaching those of the SC group, but increased MDA (p = 0.0055) levels. Additionally, oxLDL levels were positively correlated with liver stiffness measurements at SVR (p = 0.017) and at 1 year post- SVR (p = 0.002).Conclusions: Plasma oxLDL showed post-SVR normalization after clearance of HCV viremia with DAAs and was associated with levels of hepatic fibrosis.

    比較接受DAA療程且達到SVR追蹤兩年的慢性C型肝炎病人與自發性清除C型肝炎病毒且追蹤兩年的自願者血漿中氧化壓力標誌物(氧化低密度脂蛋白 (oxLDL)、8-羥基去氧鳥苷 (8-OHdG)、丙二醛 (MDA) 和缺氧修飾白蛋白 (IMA)以及肝纖維化的進展。
    與SC組別相比,在CHC 組別中的個體在未接受DAA治療時oxLDL、8-OHdG 和 IMA有更高的表現量;但MDA表現並無差異。在 SC 組別中,8-OHdG 表現量在 SVR 2 年後有升高的趨勢 (p = 0.0409),而 接受DAA 治療的 CHC 組別中顯示 oxLDL (p < 0.0001) 和 8-OHdG (p = 0.0255) 的表現量下降,且表現量與SC 組相近,但增MDA (p = 0.0055) 的表現量增加。此外,oxLDL 表現量與 SVR (p = 0.017) 和 SVR 1 年後 (p = 0.002) 的肝臟硬度測量值呈正相關。
    DAAs清除 HCV 病毒血症後,血漿 oxLDL 的表現量在 SVR 後呈現正常表現且和肝纖維化水平相關。

  • 6. A Modified 1H-NMR Quantification Method of Ephedrine Alkaloids in Ephedrae Herba Samples.

    Li, Y.-C., Wu, C.-H., Le, T. H., Yuan, Q., Huang, L., Chen, G.-F., Yang, M.-L., Lam, S.-H., Hung, H.-Y., Sun, H., Wu, Y.-H., Kuo, P.-C., & Wu, T.-S. (2023). International Journal of Molecular Sciences, 24(14), 11272. Read this article

    A previous 1H-NMR method allowed the quantification of ephedrine alkaloids; however, there were some disadvantages. The cyclized derivatives resulted from the impurities of diethyl ether were identified and benzene was selected as the better extraction solvent. The locations of ephedrine alkaloids were confirmed with 2D NMR. Therefore, a specific 1H-NMR method has been modified for the quantification of ephedrine alkaloids. Accordingly, twenty Ephedrae Herba samples could be classified into three classes: (I) E. sinica-like species; (II) E. intermedia-like species; (III) others (lower alkaloid contents). The results indicated that ephedrine and pseudoephedrine are the major alkaloids in Ephedra plants, but the concentrations vary greatly determined by the plant species and the collection locations.

    之前已報導的1H-NMR方法可以對麻黃類生物鹼進行定量,然而仍然存在一些缺點。本研究對因乙醚的雜質而產生的環化衍生物進行了鑑定,改用苯作為較佳的萃取溶劑,並通過2D NMR的使用確認了各個麻黃類生物鹼的位置。因而修改所得的1H-NMR方法對麻黃類生物鹼的定量更具有專一性。利用此方法分析收集到的20個麻黃樣品,依其結果可分為三類:(一)類草麻黃物種;(二)類中麻黃物種;(三)其他(低生物鹼含量)。 結果表明,麻黃鹼和偽麻黃鹼是麻黃屬植物中的主要生物鹼,但其濃度因植物種類和採集地點的不同而存在較大差異。

  • 7. Paper-Based Exosomal MicroRNA-21 Detection for Wound Monitoring: A Proof of Concept and Clinical Validation Trial Study.

    Pan, S.-C., Lai, C.-H., Vu, V.-T., Vu, C.-A., Huang, C.-J., Cheng, C.-M., & Chen, W.-Y. (2023). International Journal of Molecular Sciences, 24(14), 9822. Read this article

    Emerging evidence has shown that microRNAs play pivotal roles in wound healing. Exosomal miRNAs have been identified and explored as essential markers for diagnostic medicine. However, the role of exosomal miR-21 in wounds has yet to be well studied. We developed an easy-to-use, rapid, paper-based microfluidic-exosomal miR-21 extraction device to determine wound prognosis. We isolated and then quantitatively examined exosomal miR-21 in wound fluids. Eight improving wounds displayed lower levels of exosomal miR-21 expression after wound debridement. However, four instances of increased exosomal miR-21 expression levels were notably associated with patients with poor healing wounds despite aggressive wound debridement, indicating a predictive role of tissue exosomal miR-21 for wound outcome. Paper-based nucleic acid extraction device provides a rapid and user-friendly approach for evaluating exosomal miR-21 in wound fluids as a means of monitoring wounds. Our data suggest that tissue exosomal miR-21 is a reliable marker for determining current wound status.


  • 8. Effect of morphologies and compositions of silver-based multicomponent heterogeneous nanocrystals on the reduction of 4-nitrophenol.

    Huang, M.-S., Cheng, H.-T., & Hsu, S.-W. (2023). Nanoscale Advances. Read this article

    Silver-based nanocrystals have excellent catalytic performance in various reactions, such as the reduction of 4-nitrophenol. The catalytic performance of nanocrystals varies with serval parameters, including nanocrystal morphology, composition, and plasmoninduced hot electrons around nanocrystals. Here, highly heterogeneous nanocrystals (Au-Ag and Ag2S-Ag nanocrystals) fabricated on polymer films via seed-mediated are used as catalysts for the reduction of 4-nitrophenol, and the effect of the morphology and composition of nanocrystals on the catalytic performance is investigated. These nanocrystals on polymer films exhibit higher reusability (low catalysts loss) in catalytic applications compared to catalysts dispersed freely in the reaction solution. The excellent catalyst performance of these heterogeneous nanocrystals is attributed to their high surface area/volume ratio (flower-like nanocrystal) and strong synergistic effect (cage-like nanocrystals). These nanocrystals with special morphologies and composites showed higher catalytic performance (higher reactivity at lower catalysts contents) than silver-based nanocrystals reported in the literature. Due to the excellent plasmonic properties of Ag nanocrystals, the catalytic performance of these nanocrystals can be further enhanced by generating hot electrons around the nanocrystals under irradiation. These results demonstrated that by carefully controlling the morphology and composition of nanocrystals, it is possible to design and fabricate excellent catalysts for various reactions.

    銀基奈米晶體在各種反應中具有優異的催化性能,例如 4-硝基苯酚的還原。奈米 晶體的催化性能隨一些參數的變化而變化,包括奈米晶體的形態、組成和奈米晶 體周圍電漿子誘導的熱電子。這裡,通過晶種介導在高分子薄膜上製備的高度非 均質奈米晶體(Au-Ag 和 Ag2S-Ag 奈米晶體)用作 4-硝基苯酚還原之觸媒,並對 奈米晶體的形態和組成對催化性能的影響進行研究。 與自由分散在反應溶液中 的觸媒相比,固定於高分子薄膜上的奈米晶體做為觸媒中表現出更高的可再使用 性(低觸媒回收損失率)。 這些非均質奈米晶體優異的催化劑性可歸因於它們的 高表面積/體積比(花狀奈米晶體)和強的協同效應(籠狀奈米晶體)。 這些具有 特殊形態的奈米晶體比文獻報導的銀基奈米晶體表現出更佳的催化性能(在較低 觸媒含量下具有更高的反應活性)。 由於銀奈米晶體具有優異的電漿子之特性, 這些奈米晶體的催化性能可以在外照光源下,使奈米晶體周圍產生熱電子來進一 步增強催化性能。 這些結果表明通過仔細控制奈米晶體的形態和組成,可以設 計和製造出用於各種反應的優異觸媒。

  • 9. Bioengineered Bacteriophage-Like Nanoparticles as RNAi Therapeutics to Enhance Radiotherapy against Glioblastomas.

    Pang, H.-H., Huang, C.-Y., Chen, P.-Y., Li, N.-S., Hsu, Y.-P., Wu, J.-K., Fan, H.-F., Wei, K.-C., & Yang, H.-W. (2023). ACS Nano, 17(11), 10407-10422. Read this article

    Glioblastomas (GBMs) often resist radiotherapy, with many recurring post-treatment. Enhancing radiotherapy via gene-silencing has thus gained interest. However, challenges in consistent RNA loading in nanoparticles hinder clinical application. We've bioengineered bacteriophage particles with a three-way junction (b-3WJ) RNA scaffold for targeting radioresistant GBM genes. In vitro, the b-3WJ RNA cleavage by Dicer enzyme is trackable via fluorescence microscopy. Moreover, TrQβ@b-3WJ effectively silences both EGFR and IKKα genes, inhibiting the NF-κB pathway and DNA repair. Utilizing convection-enhanced delivery (CED) for TrQβ@b-3WJ, followed by 2Gy X-ray, the median survival extended to over 60 days, compared to just 31 days in the standard 2Gy X-ray group. This highlights RNAi-based strategies' potential and CED's efficacy in enhancing radiotherapy for GBMs without systemic toxicity.

    由於膠質母細胞瘤 (GBMs) 常常對放射治療產生抗性,許多病患在化療及放射治療後仍常復發。因此,透過基因沉默來增強放射治療引起了眾多關注。然而,精確調控奈米顆粒中的組成與 RNA 裝載量的困難性導致 RNA 治療產品之間存在批次間變異,這大大限制了其在臨床的應用轉化。在本研究中,我們對噬菌體顆粒進行生物基因工程修改,設計了一種三向接頭 (b-3WJ) RNA骨架,該骨架包含兩個 siRNA/miRNA 序列和一個發光適體,用於靜默放射抗性 GBM 細胞中的基因以降低 GBM 細胞放射抗性。體外試驗結果顯示,使用螢光顯微鏡可實時監測由 Dicer 酶對新設計的 b-3WJ RNA 的切割情況,且 TrQβ@b-3WJ 可同時有效靜默了 EGFR 和 IKKα 基因,進而抑制了 NF-κB 信號傳導途徑,降低 DNA 的修復能力。透過對流增強遞送 (CED) 方式投遞 TrQβ@b-3WJ,隨後進行 2Gy 的低劑量 X 射線照射,結果顯示與僅接受 2Gy X 射線照射的對照組相比,中位生存時間延長到超過 60 天 (對照組中位生存期:31天)。總之,這項研究的結果對於RNAi為基礎的遺傳治療策略設計具有關鍵意義,而CED技術作為一種有效的藥物遞送系統,有助於增強對 GBM 的放療效果並且大幅降低全身性毒性。

  • 10. Stick-slip squirmers: slip asymmetry can qualitatively change self-swimming characteristics of squirmers.

    Yang, F.-L., Chen, Y.-A., Premlata, A. R., & Wei, H.-H. (2023). Journal of Fluid Mechanics, 967, A29, Article A29. Read this article

    A stick-slip asymmetry can break the symmetry of the local hydrodynamic force distribution on the surface of an otherwise no-slip or uniform-slip particle. Here we use the Lorentz reciprocal theorem to demonstrate that such asymmetry, even in a small amount, can completely change the swimming characteristics of a self-propelled spherical squirmer, making its behavior markedly different than a no-slip or uniform-slip squirmer. We find that the swimming velocity U of a stick-slip squirmer can be driven alone by a symmetric extensile/contractile squirming from the B2 mode that commonly provides a stresslet, capable of reversing the swimming direction of the squirmer. A symmetric force dipole, namely stresslet S, can also be generated solely by a unidirectional diverging and converging squirming from the B1 mode that provides the thrust for the swimming, which can invert the stresslet of the squirmer from extensile type to contractile type or vice versa. When these two squirming modes are executing together, both U and S can be enhanced or diminished due to the interplays between asymmetric squirming forces generated by these two modes, depending on the stick-slip partition and orientation. These distinctive features arising from stick-slip asymmetry can not only be made geometrically tunable for steering the motion of a squirmer, but also provide new means for making efficient artificial microswimmers using catalytic Janus particles.

    黏滑不對稱性可以破壞無滑移或均勻滑移粒子表面上的局部流體力學受力分佈的對稱性。我們使用洛倫茨互易定理來證明,即使是微小的黏滑不對稱性也可以完全改變球形自滑粒子的自泳動特性,使其表徵與無滑移或均勻滑移的自滑粒子明顯不同。我們發現,黏滑自滑粒子的泳動速度 U 可單獨由慣常提供應力子的 B2 模式的對稱伸展/收縮方式來驅動,該模式能夠反轉自泳動方向。而對稱的力偶,即應力子 S,也可以僅通過提供泳動所需推力的單向滑游B1模式來生成,可以將自滑粒子的應力子從伸展型轉變為收縮型,反之亦然。當這兩種自滑模式一起執行時,由於這兩種模式產生的不對稱滑泳力之間的相互作用,U 和 S 可能增強或減弱。由黏滑不對稱性引起的這些獨特性質不僅可藉幾何方式調控自泳動粒子的運動,還可能為使用兩面催化粒子製備高效的人工微米自游動機帶來新的方案。

  • 11. Reducing Medication Errors by Adopting Automatic Dispensing Cabinets in Critical Care Units.

    Tu, H.-N., Shan, T.-H., Wu, Y.-C., Shen, P.-H., Wu, T.-Y., Lin, W.-L., Yang-Kao, Y.-H., & Cheng, C.-L. (2023). Journal of Medical Systems, 47(1), 52. Read this article

    Medication errors can have severe consequences and threaten patient safety. The patient safety-related benefits of automated dispensing cabinets (ADCs) have been reported by several previous studies, including a reduction in medication errors in intensive care units (ICUs) and emergency departments. However, the benefits of ADCs need to be assessed, given the different healthcare practice models. This study aimed to compare the rates of medication errors, including prescription, dispensing, and administrative, before and after using ADCs in intensive care units. The prescription, dispensing, and administrative error data before and after the adoption of ADCs were retrospectively collected from the medication error report system. The severity of medication errors was classified according to the National Coordinating Council for Medication Error Reporting and Prevention guidelines. The study outcome was the rate of medication errors. After the adoption of ADCs in the intensive care units, the rates of prescription and dispensing errors reduced from 3.03 to 1.75 per 100,000 prescriptions and 3.87 to 0 per 100,000 dispensations, respectively. The administrative error rate decreased from 0.046 to 0.026%. The ADCs decreased National Coordinating Council for Medication Error Reporting and Prevention category B and D errors by 75% and category C errors by 43%. To improve medication safety, multidisciplinary collaboration and strategies, such as the use of automated dispensing cabinets, education, and training programs from a systems perspective, are warranted.

    用藥錯誤可能引發嚴重後果,危及病人安全。先前多項研究已指出自動調劑要貴(Automated dispensing cabinets, ADCs)對於病人安全的正面效益,尤其在重症加護病房及急診部門能夠顯著減少用藥錯誤。然而,鑒於各種醫療實踐模式的差異,我們需要深入評估自動調劑藥櫃在台灣醫療環境中的實際效益。本研究的目的是比較在重症加護病房使用自動調劑藥櫃前後的用藥錯誤率,涵蓋處方、調劑及給藥等方面的錯誤。我們從用藥錯誤報告系統中回顧性地蒐集了使用自動調劑藥櫃前後的相關錯誤事件數據。所有的用藥錯誤嚴重性都依照國家藥物錯誤報告和預防協調委員會的指南進行分類。研究結果發現,在重症加護病房採用自動調劑藥櫃後,每10萬份處方和每10萬次調劑中的錯誤率從3.03和3.87分別降到1.75和0。而給藥錯誤率也從0.046%減少到0.026%。此外,自動調劑藥櫃使得按照國家藥物錯誤報告和預防協調委員會分類的B類嚴重度和D類嚴重度錯誤減少了75%,C類嚴重度錯誤則減少了43%。為了進一步提高藥物的使用安全,我們應該結合跨科部的合作,並採取加強教育與系統化培訓等策略。

  • 12. Exploring tourist preference for Mobility-as-a-Service (MaaS) – A latent class choice approach.

    Chen, C.-F., Fu, C., & Chen, Y.-C. (2023). Transportation Research Part A: Policy and Practice, 47(1), 52. Read this article

    Mobility-as-a-Service (MaaS) provides travelers with a single digital travel platform that integrates information, booking, and payment with considerable discounts. Existing MaaS studies mainly focus on commuters’ daily mobility instead of tourists’ mobility during their stay at destinations. However, the tourist market is a potential but neglected MaaS market. To explore tourist preference for MaaS bundled services, this research examines the preference heterogeneity of tourist-specific MaaS bundles among 491 Taiwanese tourists by using the latent class choice model. The choice experiments are designed by seven MaaS bundle attributes, including public transport, shared bike, shared e-moped, shared car, shopping discount, attraction ticket discount and price. Three tourist classes, namely, MaaS Skeptics, MaaS Supporters, and MaaS Enthusiasts, are identified based upon three attitudinal latent variables (hedonic motivation, Attitude toward MaaS and mobile application factor) as well as socioeconomic characteristics. The results provided evidence of a tourist-specific MaaS market and preference heterogeneity among various tourist classes in Taiwan. Class profiles and scenario analyses of pro-MaaS propensity for three classes were conducted to provide deeper insights into preference variations.

    交通行動服務方案提供旅運者一個單一的數位旅運平臺用來整合資訊、訂票以及支付具有折扣的整合方案。目前大部分的交通行動服務方案都是針對通勤者的旅運需求進行探討,但是對觀光客在目的地停留期間的旅運需求之了解仍為研究之缺口。實際上針對觀光客旅運需求所提供的交通行動方案,乃是MaaS的另外一個值得重視的利基市場。為了分析觀光客對觀光MaaS組合服務方案的需求偏好,本研究以臺灣重要觀光目的地(高雄駁二文創園區)為研究情境,利用潛在類別選擇模型(Latent Class Choice Model, LCCM)分析觀光客敘述性偏好問卷資料,以瞭解觀光客對觀光MaaS方案所重視的屬性,並透過潛在變數所得的分群,探討不同分群對需求偏好之差異,已達成對偏好異質性的掌握。選擇實驗所考慮的MaaS組合運具屬性包括公共運輸、共享單車、共享電動機車、購物折扣、觀光景點入門費折扣、以及方案價格。透過三項潛在變數(享樂動機、對MaaS的態度、及行動APP的使用態度等)進行受訪者之分群,得到3個觀光客分群,包括MaaS懷疑者、MaaS支持者、及MaaS擁護者。透過對此3個分群進行受訪者組成分析,可以提供MaaS方案行銷策略重要的訊息,進而設計適合各分群觀光客需要的組合方案。

  • 13. Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma.

    Tsai, H.-W., Chen, Y.-L., Wang, C.-I., Hsieh, C. C., Lin, Y.-H., Chu, P.-M., Wu, Y.-H., Huang, Y.-C., & Chen, C.-Y. (2023). Cancer Cell Internationall, 23(1), 42. Read this article

    Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common cancer and the second most common cause of cancer-related death worldwide. The survival rate of sorafenib-treated advanced HCC patients is still unsatisfactory. Unfortunately, no useful biomarkers have been verified to predict sorafenib efficacy in HCC.
    Results: We assessed a sorafenib resistance-related microarray dataset and found that anterior gradient 2 (AGR2) is highly associated with overall and recurrence-free survival and with several clinical parameters in HCC. However, the mechanisms underlying the role of AGR2 in sorafenib resistance and HCC progression remain unknown. We found that sorafenib induces AGR2 secretion via posttranslational modification and that AGR2 plays a critical role in sorafenib-regulated cell viability and endoplasmic reticulum (ER) stress and induces apoptosis in sorafenib-sensitive cells. In sorafenib-sensitive cells, sorafenib downregulates intracellular AGR2 and conversely induces AGR2 secretion, which suppresses its regulation of ER stress and cell survival. In contrast, AGR2 is highly intracellularly expressed in sorafenib-resistant cells, which supports ER homeostasis and cell survival. We suggest that AGR2 regulates ER stress to influence HCC progression and sorafenib resistance.
    Conclusions: This is the first study to report that AGR2 can modulate ER homeostasis via the IRE1α-XBP1 cascade to regulate HCC progression and sorafenib resistance. Elucidation of the predictive value of AGR2 and its molecular and cellular mechanisms in sorafenib resistance could provide additional options for HCC treatment.

    肝癌為全世界發生率第六且死亡率第二的癌症,其中肝細胞癌占了百分之八十。蕾莎瓦(sorafenib)增加後期肝細胞癌病人的存活時間,依然不理想,且多種副作用及產生蕾莎瓦抗藥性等現象被發現。可惜目前為止,沒有有效的生物標記可預測肝細胞癌病人對蕾莎瓦治療的效果。為達成此目標,我們將肝細胞癌對蕾莎瓦有抗藥性的細胞資料庫以及Roessler Liver microarray作分析,找尋與肝細胞癌發展及存活率有關的重要分子。目前為止,初步發現由蕾莎瓦有抗藥性的細胞資料庫中,挑選出前梯度蛋白2 (AGR2)與肝細胞癌病人的整體存活率及無復發存活率有高度相關,且與多種臨床因子有高度關聯。蕾莎瓦可能透過轉譯後修飾的方式促進前梯度蛋白2的分泌,而非轉錄調控的方式,在對蕾莎瓦敏感性的肝細胞癌細胞株中,前梯度蛋白2在蕾莎瓦調節細胞存活率、內質網壓力及促進細胞凋亡過程中,扮演重要角色。我們建立了對蕾莎瓦有抗藥性的細胞株,前梯度蛋白2在抗藥性細胞中高度表現。根據我們初步結果,我們認為前梯度蛋白2在肝細胞癌的發展及對蕾莎瓦的抗藥性,扮演重要角色。因此,我們假設在蕾莎瓦敏感性細胞中,前梯度蛋白2在細胞中含量降低,且增加分泌到細胞外,此現象會降低對內質網壓力的調節及降低細胞的存活率,另一方面,前梯度蛋白2高度表現在對蕾莎瓦有抗藥性細胞中,此現象可增加對內質網壓力的調節,提高細胞存活率。在此計畫中,我們預期前梯度蛋白2會調節肝細胞癌的內質網壓力,進而影響癌細胞的發展及蕾莎瓦的抗藥性。此計畫的完成,對於前梯度蛋白2於蕾莎瓦敏感性及抗藥性細胞中,所扮演的角色會有深入了解,可應用在發展預測性、早期診斷及預後的分子,建立治療肝細胞癌新穎的治療標的分子。

  • 14. Regional groundwater sequential forecasting using global and local LSTM models.

    Patra, S. R., Chu, H.-J., & Tatas. (2023). Journal of Hydrology: Regional Studies, 47, 101442. Read this article

    This study proposes and evaluates a Long Short-Term Memory (LSTM) model to predict daily fluctuations of regional groundwater patterns using observations across multiple monitoring wells in Choushui River Alluvial Fan located in Central Taiwan. Global models calibrated over all monitoring well data were compared with the local LSTM models each trained on the local well data for regional groundwater sequential forecast. Spatial assessment showed that the results from the local model were adversely affected when trained on data from coastal wells indicating that these areas require special attention for regional forecasting. Eventually, a fine-tuning through Transfer Learning (TL) scheme was further proposed to show considerable improvements in model performance, and to highlight the potential advantages of synthesizing cross-data information for model training when suffering from hydrogeological heterogeneity in fields.

    本研究提出並長短期記憶(LSTM)模型,運用於台灣中部濁水溪沖積扇監測井的觀測結果來預測區域地下水每日變化。根據所有監測井數據校準的全局模型與區域LSTM 模型進行比較,每個模型均根據本地井數據進行訓練,以進行區域地下水預測。當使用沿海井數據進行訓練時,區域模型的結果受到不利影響,這表示這些區域需要特別關注及預測。最終,進一步提出了藉由遷移學習(TL)方案進行微調,可獲取極大的改善。得到模型性能的改進,並強調在受現場水文地質異質性影響之數據也能直接進行模型訓練。

  • 15. An analysis of the learning styles and attitudes of foreign students in a post-baccalaureate medical education program.

    Hsu, H.-C., & Sung, T.-C. (2023). BMC Medical Education, 23(1), 497. Read this article

    In a scenario of ongoing changes in the theory and methodology of teaching, student-centered practices are crucial in improving teaching and learning outcomes. This study aimed to evaluate whether the learning styles and attitudes (connected and separate knowing) associated with the curriculum differ among medical students. The research subjects consisted of 43 first- and second-year medical students attending a post-baccalaureate medical education program exclusively for foreign students at a comprehensive university in Kaohsiung City, Taiwan. A self-administered Attitudes Toward Thinking and Learning Survey (ATTLS) was used to assess the differences in learning styles and attitudes among grades, gender, and nationality of these post-baccalaureate medical students. The reliability value of Cronbach Alpha coefficients for all items of ATTLS was 0.93. These medical students reported significantly higher connected knowing styles than separate knowing. The average score of the connected knowing for first-year students taking the "International Health" course is significantly higher than that of second-year students taking the "Population Health and Sustainable Development" course. There is no difference in the separate knowing between these two curricula. The learning styles and attitudes of students participating in the teaching process showed no difference in grade, gender, and nationality. The evidence that there is a significant interaction effect of grade, gender, and nationality examined with the separate knowing, rather than the connected knowing, suggests that this heterogenicity of learning methodology needs to be considered and integrated into future teaching methods.

    Keywords:learning styles and attitudes, post-baccalaureate, medical education

    對外國學生在學士後醫學教育課程中的學習風格和態度進行分析在不斷變化的教學理論和方法論中,以學生為中心的實踐對改善教學和學習成果至關重要。本研究旨在評估醫學生中與課程相關的學習風格和態度(聯繫求知風格(connected knowing styles)和分離知識求知風格(separate knowing style))是否有所不同。研究對象包括台灣高雄市一所綜合大學專為外國學生提供的學士後醫學教育課程的43名一年級和二年級醫學生。使用自行填寫的《思維和學習態度調查量表》(ATTLS)來評估這些學士後醫學生在年級、性別和國籍方面的學習風格和態度之間的差異。ATTLS的所有項目的Cronbach Alpha系數的可靠性值為0.93。結果發現,這些醫學生的聯繫求知風格(connected knowing styles)明顯高於分離求知風格(separate knowing style)的。一年級學生在修讀“國際健康”課程時的聯繫求知風格平均分顯著高於修讀“人口健康與可持續發展”課程的二年級學生。在這兩個課程之間的分離知識沒有差異。參與教學過程的學生的學習風格和態度在年級、性別和國籍方面沒有差異。對於分離求知風格而言,年級、性別和國籍的交互作用效應具有顯著性,而不像聯繫求知風格,這表明這種學習方法的多樣性需要納入未來的教學方法中。

  • 16. Microbial metabolites regulate social novelty via CaMKII neurons in the BNST.

    Liou, C.-W., Cheng, S.-J., Yao, T.-H., Lai, T.-T., Tsai, Y.-H., Chien, C.-W., Kuo, Y.-L., Chou, S.-H., Hsu, C.-C., & Wu, W.-L. (2023). Brain, Behavior, and Immunity, 113, 104-123. Read this article

    Social novelty is a cognitive process that is essential for animals to interact strategically with conspecifics based on their prior experiences. The commensal microbiome in the gut modulates social behavior through various routes, including microbe-derived metabolite signaling. Short-chain fatty acids (SCFAs), metabolites derived from bacterial fermentation in the gastrointestinal tract, have been previously shown to impact host behavior. Herein, we demonstrate that the delivery of SCFAs directly into the brain disrupts social novelty through distinct neuronal populations. We are the first to observe that infusion of SCFAs into the lateral ventricle disrupted social novelty in microbiome-depleted mice without affecting brain inflammatory responses. The deficit in social novelty can be recapitulated by activating calcium/calmodulin-dependent protein kinase II (CaMKII)-labeled neurons in the bed nucleus of the stria terminalis (BNST). Conversely, chemogenetic silencing of the CaMKII-labeled neurons and pharmacological inhibition of fatty acid oxidation in the BNST reversed the SCFAs-induced deficit in social novelty. Our findings suggest that microbial metabolites impact social novelty through a distinct neuron population in the BNST.


  • 17. The development of ocean governance for marine environment protection: Current legal system in Taiwan.

    Shih, Y.-C., Chen, W. C., Chen, T.-A. P., & Chang, C.-w. (2023). [Original Research]. Frontiers in Marine Science, 10. Read this article

    Since the establishment of the Ocean Affairs Council (OAC) in Taiwan in 2018, ocean governance has reached a new milestone. In 2019, the Ocean Basic Act was enacted, and in 2020, the National Ocean Policy White Paper was published, meaning that Taiwan has specialized ocean authorities, regulations, enforcement units, and relevant mechanisms and policies. The Ocean Conservation Administration (OCA) is also responsible for marine environmental protection and conservation. To ensure good ocean governance, maintain marine resources, and protect the environment, the OCA has recently drafted the Marine Conservation Act for sustainable development. This article mainly reviews, analyzes, and compares Taiwan’s current marine-related laws and regulations and refers to the laws, policies, and mechanisms of other countries to provide suggestions on marine governance and the ongoing draft of the Marine Conservation Act.

    2018年臺灣成立"海洋委員會"(OAC)以來,海洋治理邁向新的里程碑。2019 年頒布了《海洋基本法》、2020年政府公布《國家海洋政策白皮書》,這意味著臺灣有了專責的海洋主管機關、法規、執法單位以及相關機制和政策。海洋保育署(OCA)也負責海洋環境保護與保育任務。為確保良好的海洋治理、維護海洋資源、保護環境,海洋保育署最近起草了《海洋保護法》,以促進海洋的永續發展。本文主要回顧、分析和比較臺灣現行的海洋相關法律規範,並參考其他國家的法律、政策和機制,為我國海洋治理和正在起草的《海洋保育法》提供建議。

  • 18. The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer.

    Hsiao, K.-C., Ruan, S.-Y., Chen, S.-M., Lai, T.-Y., Chan, R.-H., Zhang, Y.-M., Chu, C.-A., Cheng, H.-C., Tsai, H.-W., Tu, Y.-F., Law, B. K., Chang, T.-T., Chow, N.-H., & Chiang, C.-W. (2023). Cell Communication and Signaling, 21(1), 172. Read this article

    Colorectal cancer is a leading cause of cancer mortality, which accounts for approximately 10% of cancer-related mortality in Western countries and the incidence of colorectal cancer has increased steadily in the past ten years and has recently become the most common cancer in Taiwan. Although several treatment options are available for patients of colorectal cancer, very limited options of effective therapy are applied for treating the advanced stages of colorectal cancer. Our finding reveals a novel oncogenic mechanism involving the B56γ3 regulatory subunit-containing PP2A in colorectal cancer. PP2A was previously recognized as a tumor suppressor, whereas our current finding indicates that the B56γ3 regulatory subunit can lead PP2A to downregulate p70S6K-mediated negative feedback loop on growth factor signaling, resulting in oncogenic AKT hyper-activation. Our finding suggests that the PP2A-B56γ3/p70S6K signaling module may serve as a therapeutic target to control tumor progression of colorectal cancer.

    大腸癌是導致癌症死亡的主要原因,在西方國家約佔癌症相關死亡率的 10%,近十年來,大腸癌的發病率持續上升,已成為台灣最常見的癌症。雖然大腸癌患者可以選擇多種治療方法,但用於治療晚期大腸癌的有效療法非常有限。我們的發現揭示了一種新的致癌機制,涉及大腸癌中含有 B56γ3 調節次單元的 PP2A。 PP2A 以前被認為是一種腫瘤抑制因子,而我們目前的發現顯示,B56γ3 調節次單元可引導 PP2A 下調 p70S6K 介導的生長因子信號傳遞的負反饋環調控而促成致癌性AKT激酶的過度活化。我們的發現闡明,PP2A-B56γ3/p70S6K 信號模組可作為控制大腸癌腫瘤進展的治療標的。

  • 19. Scheduling coflows for minimizing the total weighted completion time in heterogeneous parallel networks.

    Chen, C.-Y. (2023). Journal of Parallel and Distributed Computing, 182, 104752. Read this article

    Coflow is a network abstraction used to represent communication patterns in data centers. The coflow scheduling problem encountered in large data centers is a challenging NP-hard problem. Many previous studies on coflow scheduling mainly focus on the single-core model. However, with the growth of data centers, this single-core model is no longer sufficient. This paper addresses the coflow scheduling problem within heterogeneous parallel networks, which feature an architecture consisting of multiple network cores running in parallel. In this paper, two polynomial-time approximation algorithms are developed for the flow-level scheduling problem and the coflow-level scheduling problem in heterogeneous parallel networks, respectively. For the flow-level scheduling problem, the proposed algorithm achieves an approximation ratio of O(log m/ loglog m) when all coflows are released at arbitrary times, where $m$ represents the number of network cores. On the other hand, in the coflow-level scheduling problem, the proposed algorithm achieves an approximation ratio of O(m(log m/loglog m)^2) when all coflows are released at arbitrary times. Moreover, we propose a heuristic algorithm for the flow-level scheduling problem. Simulation results using synthetic traffic traces validate the performance of our algorithms and show improvements over the previous algorithm.

    Coflow是一種用於表示資料中心通訊模式的網路抽象。本論文分別為異質平行網路中的流級排程問題和coflow級排程問題開發了兩種多項式時間近似演算法。對於流級排程問題,所提出的演算法達到O(log m/ loglog m)的近似比,其中m代表網路核心的數量。另一方面,在coflow級排程問題中,所提出的演算法達到O(m(log m/loglog m)^2) 的近似比。

  • 20. Enhancement of Stability in n-Channel OFETs by Modulating Polymeric Dielectric.

    Fang, P.-H., Kuo, P.-L., Wang, Y.-W., Cheng, H.-L., & Chou, W.-Y. (2023). Polymers, 15(11), 2421. Read this article

    In this comprehensive study, we meticulously fine-tuned the solid content of polyimide (PI) to strategically enhance the surface properties of the dielectric layer in organic field-effect transistors (OFETs). Our primary objective was to mitigate defect density at the critical interface between the dielectric and the organic semiconductor layer within OFETs. Through this modulation, we achieved significant enhancements in electrical characteristics and overall stability of the OFETs. Notably, a higher solid content of the PI film directly correlated with elevated current stability in the OFET, showcasing a promising avenue for tailored device performance. Leveraging this optimized PI film in organic memory devices demonstrated remarkable attributes, notably improved storage retention and durability. These advancements pave the way for highly stable devices, making them well-suited for integration into future flexible electronic products, thereby fostering the evolution of this technology towards a more sustainable and versatile future.


  • 21. Physical therapy for sleep apnea: a smartphone application for home-based physical therapy for patients with obstructive sleep apnea [Methods].

    Bui-Diem, K., Hung, C.-H., Zhu, G.-C., Tho, N. V., Nguyen-Binh, T., Vu-Tran-Thien, Q., To-Truong, D., Ngo-Thanh, H., & Duong-Quy, S. (2023). Frontiers in Neurology, 14. Read this article

    Purpose: In this study, we described “Physical Therapy for Sleep Apnea”, a smartphone application for home-based physical therapy of patients with Obstructive Sleep Apnea.Methods: The application was created in a joint program between the University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam, and National Cheng Kung University, Taiwan. Exercises maneuvers were derived from the exercise program previously published by the partner group at National Cheng Kung University. They included exercises for upper airway and respiratory muscle training and general endurance training.Results: The application provides video and in-text tutorials for users to follow at home and a schedule function to assist the user in organizing the training program, which may improve the efficacy of home-based physical therapy in patients with Obstructive Sleep Apnea.Conclusion: In the future, our group plans to conduct a user study and randomized-controlled trials to investigate whether our application can benefit patients with Obstructive Sleep Apnea.


  • 22. When to help juveniles, adults, or both: analyzing the evolutionary models of stage-structured mutualism [Original Research]

    Nakazawa, T., Katayama, N., Utsumi, S., Yamawo, A., & Yamamichi, M. (2023). Frontiers in Ecology and Evolution, 11. Read this article

    Mutualism is common in nature and is crucial for population dynamics, community structure, and ecosystem functioning. Studies have recently pointed out that life-history stage structure (e.g., juveniles and adults) is a key factor to better understand the ecological consequences of mutualism (termed stage-structured mutualism). Despite the potential importance, little is known about what kinds of stage-structured mutualism can evolve and when it is likely to occur. Here, we theoretically investigated how a mutualistic partner species should allocate efforts of mutualistic associations for different life-history stages of its host species to maximize its fitness. We assessed the partner’s optimal strategy by using a one host–one partner model with the host’s juvenile-adult stage structure. The results showed that different forms of stage-structured mutualism can evolve, such as juvenile-specialized association, adult-specialized association, and inter-stage partner sharing (i.e., the partner associates with both the juvenile and adult stages of the host) depending on the shape of association trade-off, i.e., how much association with one stage is weakened when the partner strengthens its association with the other stage. In general, stage-specialized association (either juvenile-specialized or adult-specialized association) tends to evolve when being associated with that stage is relatively beneficial. Similarly, adult-specialized association tends to evolve if it is relatively beneficial. Meanwhile, when the association trade-off is weak, inter-stage partner sharing can occur if the mutualistic benefits of juvenile-specific and adult-specific associations are sufficiently large. We also found that when the association trade-off is strong, alternative stable states occur in which either juvenile-specialized or adult-specialized associations evolve depending on the initial trait value. These results suggest that pairwise interspecific mutualism is more complicated than previously thought, implying that we may under- or overestimate the strength of mutualistic interactions when looking at only certain life-history stages. This study provides a conceptual basis for better understanding the mechanisms underlying ontogenetic shifts of mutualistic partners and more complex mutualistic networks mediated by the life-history stages of organisms and their stage-structured interactions.



  • 23. Quantification of vessel separation using the carotid-jugular angle to predict the nerve origin of neck peripheral nerve sheath tumours: a pooled analysis of cases from the literature and a single-center cohort.

    Wong, C.-E., Huang, C.-C., Chuang, M.-T., Lee, P.-H., Chen, L.-Y., Hsu, H.-H., Huang, C.-Y., Md, P., Wang, L.-C., Lee, J.-S., & Md, M. (2023). Int J Surg, 109(9), 2704-2713. Read this article


    Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumours (PNSTs). Accurate preoperative identification of the nerve origin (NO) can improve surgical outcomes and patient counselling.

    Material and methods:

    This study was a retrospective cohort and quantitative analysis of the literature. The authors introduced a parameter, the carotid-jugular angle (CJA), to differentiate the NO. A literature review of neck PNST cases from 2010 to 2022 was conducted. The CJA was measured from eligible imaging data, and quantitative analysis was performed to evaluate the ability of the CJA to predict the NO. External validation was performed using a single-centre cohort from 2008 to 2021.


    In total, 17 patients from our single-centre cohort and 88 patients from the literature were analyzed. Among them, 53, 45, and 7 patients had sympathetic, vagus, and cervical nerve PNSTs, respectively. Vagus nerve tumours had the largest CJA, followed by sympathetic tumours, whereas cervical nerve tumours had the smallest CJA (P<0.001). Multivariate logistic regression identified a larger CJA as a predictor of vagus NO (P<0.001), and receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) of 0.907 (0.831–0.951) for the CJA to predict vagus NO (P<0.001). External validation showed an AUC of 0.928 (0.727–0.988) (P<0.001). Compared with the AUC of the previously proposed qualitative method (AUC=0.764, 0.673–0.839), that of the CJA was greater (P=0.011). The cut-off value identified to predict vagus NO was greater than or equal to 100°. Receiver operating characteristic analysis showed an AUC of 0.909 (0.837–0.956) for the CJA to predict cervical NO (P<0.001), with a cut-off value less than 38.5°.


    A CJA greater than or equal to 100° predicted a vagus NO and a CJA less than 100° predicted a non-vagus NO. Moreover, a CJA less than 38.5 was associated with an increased likelihood of cervical NO.

    頸部是周邊神經鞘腫瘤(peripheral nerve sheath tumor)最好發的部位,在這個狹小的空間內,除了左右各有兩條重要的血管外,還有多條重要的神經,包括迷走神經(vagus nerve)、交感神經(sympathetic nerve)、頸神經(spine nerve);對周邊神經鞘腫瘤的治療,手術切除是唯一的治療方式,但是術中的神經損傷所造成術後神經麻痺是最主要的併發症,因為目前無有效且準確的術前診斷方式來判定腫瘤的來源神經,所以醫師無法有效率和準確地執行術中神經監測,病人也無法在術前得知手術可能危及的神經和相對應的手術風險;為了解決這個臨床治療的難題,我們利用頸部血管、腫瘤、來源神經解剖位置的相對關係提出了一個新的參數: 頸動脈-頸靜脈角(carotid-jugular angle, CJA),假設這個角度會因為腫瘤的來源神經不同分別有相對應的角度,用以辨別周邊神經鞘腫瘤的來源神經。首先,利用大體老師(cadaveric neck)來建立頸動脈-腫瘤-頸靜脈的示意模型;回顧分析我個人過去自2008年至2021年所有手術案例,利用2010年至2022年文獻中周邊神經鞘腫瘤的影像資料來執行外部驗證,總共分析了院內的17名患者與文獻中的88名患者影像的頸動脈-頸靜脈角,其中53名患者的來源神經為交感神經、45名為迷走神經、7名為頸椎神經根。迷走神經鞘瘤有最大的頸動脈-頸靜脈角,其次為交感神經鞘瘤,頸椎神經根瘤的角度則最小。利用多變量邏輯回歸分析和ROC曲線分析顯示預測迷走神經鞘瘤的截斷值為 ≥1000,預測頸神經根神經鞘瘤的截斷值為 < 8.50。

    所以,利用術前的CT或 MRI,當周邊神經鞘腫瘤的頸動脈-頸靜脈角≥1000,可預測為迷走神經鞘瘤,頸動脈-頸靜脈角< 100°且 > 38.50,則可預測為交感神經瘤,頸動脈-頸靜脈角< 38.50則為頸神經鞘瘤,此方法可以簡單而且準確地在術前準斷出腫瘤的來源神經,醫生可以有目標的執行手術和神經監測、病患可以清楚知道可能的併發症,此方法是目前世界上唯一的客觀術前診斷方式。

  • 24. Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin.

    Chiu, Y.-C., Yeh, M.-C., Wang, C.-H., Chen, Y.-A., Chang, H., Lin, H.-Y., Ho, M.-C., & Lin, S.-M. (2023). Nature Communications, 14(1), 5946. Read this article

    The Vibrio α-hemolysin is a β-pore-forming toxin secreted by Vibrio bacteria, crucial for enhancing bacterial infections. In our study on Vibrio campbellii α-hemolysin (VcαHL), we found that its hemolytic activity is significantly elevated under the induction of calcium ions. We further investigated how calcium ions promote the assembly of VcαHL on the cell membrane. Using X-ray crystallography and cryo-electron microscopy, we presented the precursor and assembled structures of VcαHL. Notably, VcαHL contains a calcium-binding site, playing a pivotal role in its activation. These novel findings provide a new direction for therapeutic strategies against Vibrio infections.


  • 25.Impact of infection-related admission in patients with heart failure: a 10 years national cohort study.

    Chen, C.-Y., Lee, C.-H., Lin, H.-W., Lin, S.-H., & Li, Y.-H. (2023). Scientific Reports, 13(1), 6941. Read this article

    Infection is a common cause of hospitalization in patients with heart failure (HF). The impact of infection on long term cardiovascular outcome in HF is not well studied. The aim of this study was to compare the long-term risk of major adverse cardiovascular events (MACE) in HF patients with or without prior hospitalization for infection. From 2009 to 2015, 310,485 patients with their first HF admissions were enrolled from the Taiwan National Health Insurance Research Database. Among the patients, those with readmission due to infection within one year after HF discharge were defined as infection group and those without any infection admission were controls. The propensity score matching method was used to balance covariates between the two groups. In a mean follow-up time of 4.29 ± 2.92 years, 86.19% of patients in the infection group and 63.63% of patients in the control group had MACE. Multivariate Cox proportional hazards analysis showed the infection group had a higher risk of MACE, including all-cause mortality, myocardial infarction, stroke and hospitalization for HF. In conclusion, many HF patients discharged from the hospital experienced acute infection that required readmission. The patients had worse cardiovascular outcome after readmission for infectious disease compared to those without any infection.


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