獲得圖書館OA補助文章之介紹 (服務辦法)
  • 1. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer

    Ding et al. (2020) Clinical Epigenetics, 12(1), 87. Cite this article

    Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer (PDA). By analyzing PDA subtypes in The Cancer Genome Atlas, we identified that epigenetic silencing of Apoptosis Associated Tyrosine Kinase (AATK) inversely was correlated with mRNA expression and was enriched in the quasi-mesenchymal cancer subtype. By comparing early mouse pancreatic lesions, the non-invasive regions showed AATK co-expression in cells with acinar-to-ductal metaplasia, but the invasive lesions revealed diminished AATK expression in cells with poorly differentiated histology. Transiently activated AATK initiates acinar differentiation into a ductal cell fate to establish apical-basal polarization in acinar-to-ductal metaplasia. Silenced AATK and ectopically expressed p63 and HNF1α allow the proliferation of ductal PanINs in mice. Epigenetic silencing of AATK regulates the cellular transdifferentiation, proliferation, and cell cycle progression in converting PDA-subtypes.

    癌症亞型轉換涉及腫瘤微環境中的癌細胞起源,細胞命運決定以及細胞的轉分化,在胰臟癌至今仍是主要問題。藉由分析癌症基因組圖譜資料庫(TCGA)中的胰臟癌資料,我們發現凋亡相關酪氨酸磷酸酶基因AATK的表觀遺傳標定與mRNA表達成反比,此異常特徵富含於類間質腫瘤亞型。於小鼠早期胰臟組織病變發現,非侵入型病變細胞於此腺泡至導管轉分化時期仍有AATK蛋白表達,但在侵入型癌細胞病變則顯示出細胞分化不佳以及AATK蛋白表達減少的現象。AATK蛋白活化與腺泡至導管的型態轉換過程相關,並以此建立細胞的頂端-基底細胞極性。表觀遺傳默化的AATK基因和p63及HNF1α在小鼠胰臟上皮細胞病變增殖時期的異常表達相關。AATK基因的表觀遺傳默化在胰臟癌亞型轉化過程中的細胞轉分化,增殖和細胞週期進程具有調節能力與角色。

  • 2. Evaluation of Vertical Ground Reaction Forces Pattern Visualization in Neurodegenerative Diseases Identification Using Deep Learning and Recurrence Plot Image Feature Extraction.

    Lin et al. (2020) Sensors, 20(14), 3857. Cite this article

    To diagnose neurodegenerative diseases (NDDs), physicians have been clinically evaluating symptoms. However, these symptoms are not very dependable—particularly in the early stages of the diseases. This study has therefore proposed a novel classification algorithm that uses a deep learning approach to classify NDDs based on the recurrence plot of gait vertical ground reaction force (vGRF) data. In the preprocessing process, the 5-min vGRF data divided into 10-s successive time windows. In the feature transformation process, the time-domain vGRF data are modified into an image using a recurrence plot. The principal component analysis (PCA) is used in this stage for feature enhancement. Lastly, the convolutional neural network (CNN), as a deep learning classifier, is employed in the classification process and evaluated using the leave-one-out cross-validation (LOOCV). The experimental results included two-class and multiclass classifications with the best average accuracy were 98.65% and 97.86%, respectively.

    為了診斷神經退化性疾病(NDDs),醫師們已在臨床上評估其症狀。然而這些症狀卻不是相當可靠,尤其是在疾病早期的階段。這項研究便提出一種深度學習方式使用基於步態垂直地面反應力(vGRF)遞迴圖的創新分類演算法達到對神經退化性疾病分類。在前處理中,將5分鐘的垂直地面反應力資料切割成每10秒的連續時間視窗。在特徵轉換過程中,時域的垂直地面反應力資料被轉成遞迴圖影像。主成分分析(PCA)被用以特徵強化。最後分類的過程中,以深度學習卷積類神經網路(CNN)作為分類器,並使用留一交叉驗證法(LOOCV)進行評估。實驗的分類結果包含兩類與多類,其最佳平均準確率分別為98.65%與97.86%。

  • 3. Differentiating anomalous disease intensity with confounding variables in space.

    Wu, C.-C., & Shete, S. (2020). International Journal of Health Geographics, 19(1), 37. Cite this article

    With the identification of disease clusters of statistical significance, to determine whether or not the detected disease clusters can be explained by known or suspected risk factors is a logical next step. The models allowing for confounding variables permit the investigators to determine if some risk factors can explain the occurrence of geographical clustering of disease incidence and to investigate other hidden spatially related risk factors if there still exist geographical disease clusters, after adjusting for risk factors.We propose to develop statistical methods for differentiating incidence intensity of geographical disease clusters of peak incidence and low incidence in a hierarchical manner, adjusted for confounding variables.With the information on hierarchy in adjusted intensity levels, epidemiologists and public health officials can better prioritize the regions with the highest rates for thorough etiologic studies, seeking hidden spatially related risk factors and precisely moving resources to areas with genuine highest abnormalities.

    加入共變量調整危險因子後,來辨別地域群聚內不同疾病強度的統計方法,可以在地圖上分別建構彼此相鄰並具有不同強度的高風險區與低風險區的階級式(強度方面)群聚。隨著模型加入共變量進行調整,研究人員能夠決定一些風險因子是否可以解釋彼此相鄰的高風險區或低風險區中地域群聚的發生。

  • 4. Long Short-Term Memory Approach to Estimate Battery Remaining Useful Life Using Partial Data.

    Chinomona, B., Chung, C., Chang, L.-K., Su, W.-C., & Tsai, M.-C. (2020). IEEE Access, 8, 165419–165431.Cite this article

    Due to the increasing demand of electrical vehicles, prognostics of the battery state is of paramount importance. The nonlinearity of the signal results in the complexity of analyzing the degradation of the battery. The drawbacks of the previous prediction algorithms are insufficient or irrelevant features to explicitly model the battery aging and use of fully charged/discharged datasets, which might result in poor prediction accuracy. Therefore, this study proposes a feature selection technique to adequately select optimum statistical feature subset and the use of partial data to determine the battery remaining useful life (RUL). The proposed approach demonstrated exceptional RUL prediction results, with RMSE of 0.00286 and MAE of 0.00222 using partial discharge data. The method shows prediction in comparison with the use of full data and state-of-the-art outcomes from previous studies of the same open data from the National Aeronautics and Space Administration prognostic battery data sets.

    由於電動車的需求增加,對於電池狀態的預知也變得非常重要,而電池相關訊號的非線性讓電池衰退的分析變得複雜。因此,本研究提出了新的特徵選擇技術來選用合適的特徵組合,並以部分資料的方式來進行電池剩餘壽命預估,利用使用部分資料的技術可以得到0.00288的均方根誤差以及0.00222的平均絕對誤差。對照其他學者使用同樣美國太空總署公開電池充放電資料所得的研究成果,此研究提出的方法展現了更好的準確度。

  • 5. Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats.

    Lee, J.-S., Hsu, Y.-H., Chiu, Y.-S., Jou, I.-M., & Chang, M.-S. (2020). Journal of Neuroinflammation, 17(1), 156. Cite this article

    Spinal cord injury (SCI) causes neurological devastating consequences, which result in partial or total paralysis. The irreversible neurological deficits and glial scar formation are characteristic of SCI. Inflammatory responses play a central role in regulating the pathogenesis of SCI. IL-20 is a proinflammatory cytokine involved in renal fibrosis and liver cirrhosis through upregulating TGF-β1 production. However, the role of IL-20 in SCI remains unclear. We used the in-vivo and in-vitro studies to delineate the association between IL-20 and SCI. We found that IL-20 was highly expressed in spinal cord after SCI in rats and upregulated the expression levels of inflammatory cytokines, whereas anti-IL-20 mAb 7E treatment remarkably inhibited the inflammatory response through inhibiting the levels of IL-20 and TGF-β1. Both motor and sensory functions were improved with anti-IL-20 mAb 7E treatment. These findings give evidence that IL-20 may be a promising target for SCI treatment.

    脊髓損傷會因為神經功能障礙造成永久癱瘓,神經損傷的不可逆性和神經疤痕的形成是脊髓損傷的主要特徵,其中發炎反應是脊髓損傷最重要的致病機轉,介白質-20(IL-20)是一種前驅發炎反應的細胞激素,參與很多臨床疾病相關發炎反應,例如肝硬化、慢性腎衰竭等,目前並無相關的研究在於脊髓損傷方面。我們利用動物和細胞實驗來研究介白質-20對外傷性脊髓損傷影響。我們發現損傷後會大量表現介白質-20,在抑制介白質-20後相關的發炎反應都大量降低,同時在運動和感覺功能上有顯著的進步,這些發現提供了未來利用抑制介白質-20在治療脊椎損傷的治療方向。

  • 6. Progress in biomass torrefaction: Principles, applications and challenges.

    Chen, W.-H., Lin, B.-J., Lin, Y.-Y., Chu, Y.-S., Ubando, A. T., Show, P. L., Ong, H. C., Chang, J.-S., Ho, S.-H., Culaba, A. B., Pétrissans, A., & Pétrissans, M. (2021). Progress in Energy and Combustion Science , 82, 100887. Cite this article

    The development of biofuels has been considered as an important countermeasure to abate anthropogenic CO2 emissions and greenhouse effect. Thermochemical conversion processes are considered as the most efficient routes. In recently developing biomass conversion technologies, torrefaction has attracted much attention since it can effectively upgrade solid biomass and produce coal-like fuel. To provide a comprehensive review of the progress in biomass torrefaction technologies, this study performs an in-depth literature survey of torrefaction principles, processes, systems, and identifies a current trend in practical torrefaction development, and environmental performance. Moreover, the encountered challenges and perspectives from torrefaction development are underlined. Integrating torrefaction with other processes such as co-firing, gasification, pyrolysis, and ironmaking, etc., makes it more efficient and economically feasible in contrast to using a single process. By virtue of capturing carbon dioxide during the growth stage of biomass, negative carbon emissions can even be achieved from torrefied biomass.

    生質燃料的開發是減緩溫室效應的重要途徑,焙燒被認為是最有效的熱化學轉化技術,由於焙燒產出之固體燃料可用於替代煤炭,本研究對焙燒原理、程序及系統進行廣泛的文獻整理,並歸納焙燒技術當前在實際應用和環境效益的趨勢,亦強調焙燒技術開發的瓶頸。研究顯示將焙燒與混燒、氣化、熱裂解等製程進行整合能提升系統效率。

  • 7. Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target.

    Lai, Y.-C., Chao, C.-H., & Yeh, T.-M. (2020). Microorganisms , 8(6). Cite this article

    Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.

    登革病毒感染是最普遍的蚊媒病毒感染,可導致嚴重的登革出血熱甚至威脅生命的登革休克綜合徵。儘管已經知道細胞激素風暴是登革熱的關鍵因素,但是對登革熱免疫發病機制的了解仍有限,因此阻礙了有效治療方法的發展。巨噬細胞移動抑制因子(MIF)是一種多效性促炎細胞激素,可介導多種免疫反應,並且MIF的血清濃度與登革熱患者的疾病嚴重程度呈正相關。 目前已知MIF參與登革病毒感染期間的許多病理變化,例如血管滲漏。本文綜述了登革病毒感染過程中MIF的致病機轉和MIF分泌的調控。此外,也討論了MIF是否是抗登革病毒感染的潛在治療靶標。

  • 8. Global greenness in relation to reducing the burden of cardiovascular diseases: ischemic heart disease and stroke.

    Asri, A. K., Yu, C.-P., Pan, W.-C., Guo, Y. L., Su, H.-J., Lung, S.-C. C., Wu, C.-D., & Spengler, J. D. (2020).Environmental Research Letters , 15(12), 124003. Cite this article

    This ecological study aimed to identify the association between greenness and cardiovascular diseases in terms of ischemic heart disease (IHD) and stroke in 183 countries worldwide. The country-level disability-adjusted life year (DALY) database provided by the WHO was used to represent the health burden due to IHD and stroke for the study countries. Normalized Difference Vegetation Index (NDVI) was assessed to estimate the greenness in each country. After considering potential covariates, the generalized linear mixed model penalized quasi-likelihood (GLMMPQL) was applied to identify the greenness in relation to DALY loss due to IHD and stroke. A consistently significant negative association was found between greenness and both IHD and stroke; the NDVI coefficients of the main model were -11.245 (95% CI: -16.770, -5.720) and -4.387 (95% CI: -7.926, -0.085), respectively, in the DALY changes based on the increase of NDVI from 0 to 1.

    本研究利用世界衛生組織提供之全球失能調整生命年資料庫,代表由於缺血性心臟病與中風所造成之疾病負擔;以及衛星常態化差異植生指標,以量化各國之綠覆情況,經由廣義線性混合模式,分析環境綠蔽度與心血管疾病之關聯。結果發現,在校正風險因子的情況下,綠蔽度與缺血性心臟病及中風具顯著負相關。

  • 9. Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes.

    Chen, M. Y., Chen, J. W., Wu, L. W., Huang, K. C., Chen, J. Y., Wu, W. S., Chiang, W. F., Shih, C. J., Tsai, K. N., Hsieh, W. T., Ho, Y. H., Wong, T. Y., Wu, J. H., & Chen, Y. L. (2020).Journal of Dental Research. Cite this article

    Most oral squamous cell carcinoma (OSCC) tumors arise from oral premalignant lesions. Oral submucous fibrosis (OSF) is a premalignant stromal disease characterized by a high malignant transformation rate and high prevalence. Although a relationship between the inhabited microbiome and carcinogenesis has been proposed, the changes of the salivary microbiome during cancer formation remain unclear. This study compared the salivary microbiomes of male patients with OSCC and a predisposing OSF background (OSCC-OSF group). The results of high-throughput sequencing of the bacterial 16S rRNA gene indicated that the microbiome profile of OSF-related malignancy was associated with increased microbial stochastic fluctuation. Artificial intelligence selection algorithms consistently identified 5 key species in the OSCC-OSF group. Robust accuracy in predicting oral carcinogenesis was obtained with our exploratory and validation data sets. In conclusion, our results provided new insights into salivary microbiome alterations during the malignant transformation of OSF.

    口腔粘膜下纖維化(OSF)一種口腔癌前病變,常惡轉為口腔癌(OSCC)。微生物常被視為人類第二套基因組和人類健康及疾病關係密切,本研究利用分析唾液微生物組的變化,期望找到影響OSF惡轉為OSCC的關鍵微生物群。我們發現在OSCC唾液微生物組的共生網絡崩潰,且以人工智慧演算法找出OSCC組中的5個關鍵微生物物種可以預測口腔癌的發生。

  • 10. Anti-Cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis.

    Chang, M.-M., Hong, S.-Y., Yang, S.-H., Wu, C.-C., Wang, C.-Y., & Huang, B.-M. (2020).International Journal of Molecular Sciences,21(21). Cite this article

    Cordycepin, a bioactive constituent from the fungus Cordyceps sinensis, could inhibit cancer cell proliferation and promote cell death via induction of cell cycle arrest, apoptosis and autophagy. We observed that cordycepin down-regulated the mRNA levels of FGF9, FGF18, FGFR2 and FGFR3 genes in MA-10 cells. The in vitro study revealed that cordycepin decreased FGF9-induced MA-10 cell proliferation by inhibiting p-ERK1/2, p-Rb and E2F1 expressions, and reducing the expressions of cyclins and CDKs. Moreover, an allograft model was performed with FGF9 intratumoral injection and/or intraperitoneal cordycepin injection to MA-10-tumor bearing C57BL/6J mice. Results showed that FGF9-induced tumor growth in cordycepin-treated mice was significantly smaller than PBS-treated control group. Furthermore, cordycepin decreased FGF9-induced FGFR1-4 protein expressions in vitro and in vivo. In summary, cordycepin inhibited FGF9-induced testicular tumor growth by suppressing the ERK1/2, Rb/E2F1, cell cycle pathways, and FGFR1-4 expressions, suggesting cordycepin can be used as novel anticancer drug for testicular cancers.

    蟲草素是具有抗腫瘤作用的冬蟲夏草萃取物。微陣列分析顯示,蟲草素會降低MA-10細胞中纖維母細胞生長因子九(FGF9)與其受體基因表達。蟲草素也可顯著降低FGF9對MA-10細胞增生作用。蟲草素亦可抑FGF9處理的MA-10細胞中pRb、E2F1、cyclins、CDKs與FGFR1-4蛋白表達。蟲草素也能夠抑制FGF9處理的小鼠皮下腫瘤生長。因此,蟲草素具有治療睾丸癌症的新型抗癌藥物。

  • 11. Investigation of Ga2O3-Based Deep Ultraviolet Photodetectors Using Plasma-Enhanced Atomic Layer Deposition System.

    Chu, S.-Y., Shen, M.-X., Yeh, T.-H., Chen, C.-H., Lee, C.-T., & Lee, H.-Y. (2020). Sensors,20(21). Cite this article

    In this work, the gallium oxide (Ga2O3) films were deposited using a plasma-enhanced atomic layer deposition system. The performance of the Ga2O3 films annealed at various temperatures was investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and photoluminescence (PL). According to the measurement results, the performance of the Ga2O3 films was improved with the annealed temperature increase. The Ga2O3 films were applied to the deep metal-semiconductor-metal ultraviolet C photodetectors (MSM UVC-PDs). The cut-off wavelength and the photoresponsivity of the MSM UVC-PDs were 250 nm and 22.19 A/W, respectively.

    此研究中使用電漿增強式原子層沉積系統沉積氧化鎵薄膜,並研究在不同溫度下熱退火處理對氧化鎵薄膜特性之影響,利用X光繞射光譜、X光光電子能譜與光致發光光譜的量測結果顯示氧化鎵薄膜品質隨著退火溫度升高而有改善趨勢。將此氧化鎵薄膜應用於金屬-半導體-金屬深紫外光光檢測器,其元件截止波長為250 nm及響應度為22.19 A/W。

  • 12. Dynamic Modeling and Experimental Validation of an Impact-Driven Piezoelectric Energy Harvester in Magnetic Field.

    Chen, C.-D., Wu, Y.-H., & Su, P.-W. (2020). Sensors,20(21), 6170. Cite this article

    In this study, an impact-driven piezoelectric energy harvester (PEH) in magnetic field is presented. The PEH consists of a piezoelectric cantilever beam and plural magnets. The impact between magnets produces an impact energy and causes a transient beam vibration. The electric energy is generated by the piezoelectric effect. Based on the energy principle, a multi-degree of freedom mathematical model was developed to calculate the displacements, velocities, and voltage outputs of the PEH. A prototype of the PEH was fabricated. The maximum generated energy was about 0.4045 mJ for a single impact. A comparison between numerical and experimental results was presented in detail. It showed that the predictions based on the model agree with the experimental measurements. The PEH was connected to a diode bridge rectifier and a storage capacitor. The experiments showed that the energy stored in the capacitor can light up the LED.

    本研究提出一種由磁力產生撞擊驅動之壓電獵能器,並發展多自由度之數學模型,可計算獵能器做動時之位移、速度以及電壓輸出。本研究亦完成獵能器原型實作,單次撞擊可獵取0.4045 mJ之能量,顯示數學模型可正確預測獵能器之發電性能。壓電獵能器亦接上橋式整流器,將獵取之電荷儲存於電容中,並將電容儲存之電能釋放,點亮LED燈。

  • 13. Single Crystalline Higher Manganese Silicide Nanowire Arrays with Outstanding Physical Properties through Double Tube Chemical Vapor Deposition.

    Shen, C.-L., Yang, S.-M., & Lu, K.-C. (2020). Nanomaterials, 10(9), 1880. Cite this article

    In this work, we report a novel and efficient silicidation method to synthesize higher manganese silicide (HMS) nanowires with interesting characterization and physical properties. High density silicon nanowire arrays fabricated by chemical etching reacted with MnCl2 precursor through a unique double tube chemical vapor deposition (CVD) system, where we could enhance the vapor pressure of the precursor and provide stable Mn vapor with a sealing effect. It is crucial that the method enables the efficient formation of high quality higher manganese silicide nanowires without a change in morphology and aspect ratio during the process. X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to characterize the HMS nanowires. High-resolution TEM studies confirm that the HMS nanowires were single crystalline Mn27Si47 nanowires of Nowotny Chimney Ladder crystal structures. The excellent physical properties of the HMS nanowires (NWs) make them attractive choices for applications in spintronic devices and field emitters.

    此研究中,我們使用一種新穎而有效的矽化方法,合成富矽化錳奈米線。通過化學蝕刻製造高密度的矽奈米線陣列且通過獨特的雙管化學氣相沉積系統與前驅物反應。在該系統中,我們增強前驅物的蒸氣壓並提供具有密封效果的穩定錳蒸氣。此方法有效形成高質量的富矽化錳奈米線,而且在過程中不會改變形貌和高寬比。富矽化錳奈米線的優異物理特性使其可望應用於自旋電子元件與場發射器。

  • 14. Chitosan Oligosaccharides Suppress Nuclear Factor-Kappa B Activation and Ameliorate Experimental Autoimmune Uveoretinitis in Mice.

    Hsu, S.-M., Yang, C.-H., Tsai, H.-Y., Lin, C.-J., Fang, Y.-H., Shieh, C.-C., & Chen, S.-H. (2020). International Journal of Molecular Sciences, 21(21). Cite this article

    We investigated the therapeutic potential and mechanism of chitosan oligosaccharides (COS) for experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid binding protein (IRBP) peptides. At the same time, a high or low dose (20 or 10 mg/kg) of COS or phosphate buffered saline (PBS) was given to mice daily after EAU induction. We found that mouse EAU is ameliorated by the high-dose COS treatment when compared with PBS treatment. In the retinas of high-dose COS-treated mice, the nuclear translocation of NF-κB subunit (p65) was suppressed, and the expression of several key EAU inflammatory mediators, IFN-γ, TNF-α, IL-1α, IL-4, IL-5, IL-6, IL-10, IL-17, and MCP-1 was lowered. These results suggest that COS might be a potential treatment for posterior uveitis.

    背景:葡萄膜炎是造成眼睛視力喪失主要原因之一,非感染造成之自體免疫性後葡萄膜視網膜炎對視力影響比前葡萄膜炎更大,目前主要使用類固醇來控制與治療,但有明顯副作用如白內障與青光眼等,殼聚醣(chitosan)來自於甲殼素部分分解而成,已知有許多生物活性如抗癌、抗菌、抗發炎、抗氧化與抗凋亡等,在本研究中我們想探討殼聚醣在小鼠對實驗性自體免疫性葡萄膜視網膜炎之治療潛力與機制。

    方法:藉由在B6小鼠注射人類感光體間類視黃醇結合蛋白(IRBP)胜肽可誘發實驗性自體免疫性葡萄膜視網膜炎。在誘發的同時開始,我們每天注射高與低劑量的殼聚醣做治療或是每天注射磷酸鹽緩衝溶液作為對照。我們也取下小鼠的神經視網膜做發炎介質之分析與研究核因子κB(NF-κB)是否活化。

    結果:首先我們發現與對照組(注射磷酸鹽緩衝溶液)的小鼠相比,每天注射高劑量殼聚醣的小鼠其誘發的實驗性自體免疫性葡萄膜視網膜炎明顯減弱,在臨床眼底觀察與摘下眼睛做H&E切片染色皆可看到相似結果,同時我們發現在高劑量殼聚醣治療的小鼠其視網膜上核因子κB往核內易位明顯受到抑制,且許多種關鍵性的發炎介質包括IFN-γ,TNF-α,IL-1α,IL-4,IL-5,IL-6,IL-10,IL-17與MCP-1都有顯著下降,

    結論: 在本研究中我們證實殼聚醣的治療確實可以經由抑制核因子κB的活化減緩實驗性自體免疫性葡萄膜視網膜炎之嚴重程度,未來殼聚醣有可能用來治療人類非感染性後葡萄膜炎。

  • 15. Direct synthesis of monolayer gold nanoparticles on epoxy based photoresist by photoreduction and application to surface-enhanced Raman sensing.

    Chen, Y.-J., Chang, W.-H., Li, C.-Y., Chiu, Y.-C., Huang, C.-C., & Lin, C.-H. (2021).Materials & Design, 197, 109211. Cite this article

    The photoreduction method is a potential method in terms of simplification, speed, and cost of the process. This paper presents a simple, novel, and inexpensive method for the direct synthesis of a gold nanoparticle (AuNP) monolayer with a droplet of gold precursor on the surface of SU-8 under UV exposure, and its application to surface enhanced Raman sensing (SERS). TEM study revealed that a monolayer of AuNPs with an fcc crystalline structure was reduced on the surface of SU-8. The interparticle spacing and particle size were adjustable by controlling SU-8 initial curing time and repeated reduction. Photoreduction on SU-8 nanostructures was also achievable. The nanopillars' high specific surface area can help improve the density of the SERS hot spots, thereby effectively improving the analyte's Raman signal. The AuNPs/nanopillar substrate was applied to the detection of malachite green (aquaculture drug), and the sensitivity is enough to meet the EU regulations.

    應用光還原法生成金奈米粒子,在製程的簡化、速度與成本上都極具潛力。本研究提出一個簡單、新穎且便宜的方法,將滴在SU-8表面上的氯金酸液滴進行UV曝光,製作出單層金奈米粒子並應用於表面增強拉曼感測。SU-8的初始固化時間與重複還原的次數可以調控金奈米粒子的密度與粒徑,透過這兩個參數的調控與SU-8奈米柱結構高比表面積的特性能提升表面增強拉曼散射熱點的強度與密度,進而有效提高待測物的拉曼訊號。此金奈米粒子/奈米柱基板可用來檢測水產用藥(孔雀石綠),靈敏度能滿足歐盟判定漁貨殘留藥物含量之標準。

  • 16. Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.

    Huang, L.-Y., Hsieh, Y.-P., Wang, Y.-Y., Hwang, D.-Y., Jiang, S. S., Huang, W.-T., Chiang, W.-F., Liu, K.-J., & Huang, T.-T. (2020). International Journal of Molecular Sciences, 21(21). Cite this article

    在小鼠模型中不同階段口腔癌致癌的單細胞分析
    口腔癌爲涉及正常粘膜發展為潛在的惡性疾病,最後發展為癌症之病症。 腫瘤是異質的,具有表達不同基因並表現出不同行為的不同細胞族群。 本研究用4-硝基喹啉1-氧化物(4-NQO)和檳榔鹼誘導小鼠發生口腔癌,並通過單細胞RNA測序分析確定影響癌變基因表達的主要因素。

  • 17. A New High Entropy Glycerate for High Performance Oxygen Evolution Reaction.

    Nguyen, T. X., Su, Y.-H., Lin, C.-C., Ruan, J., & Ting, J.-M. (2021). Advanced Science, 2002446. Cite this article

    Herein, a new high entropy material is reported, i.e., a noble metal‐free high entropy glycerate (HEG), synthesized via a simple solvothermal process. The HEG consists of 5 different metals of Fe, Ni, Co, Cr, and Mn. The unique glycerate structure exhibits an excellent oxygen evolution reaction (OER) activity with a low overpotential of 229 and 278 mV at current densities of 10 and 100 mA cm−2, respectively, in 1 m KOH electrolyte, outperforming its subsystems of binary‐, ternary‐, and quaternary‐metal glycerates. The HEG also shows outstanding stability and durability in the alkaline electrolyte. The result demonstrates the significance of synergistic effect that gives additional freedoms to modify the electronic structure and coordination environment. Moreover, HEG@HEG electrolyzer shows a good overall water splitting performance and durability, requiring a cell voltage of 1.63 V to achieve a current density of 10 mA cm−2.

    新穎高熵甘油酸酯氧釋放反應催化劑
    本研究透過簡易的溶劑熱合成法合成無貴金屬之高熵甘油酸酯(HEG)。此HEG由鐵、鎳、鈷、鉻和錳5種不同的金屬組成,其獨特的甘油酸酯結構展現出優異的氧釋放反應活性,在1M KOH電解液中分別可在10和100 mA cm-2電流密度下獲得229和278 mV優異的低過電位,更勝於其二、三與四元金屬系統,同時更有著出色的穩定性和耐久性,顯現了協同效應在高熵材料中的重要性。

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